Depression and Insight 

 
   Lead Investigator:    Po H. Lu
   Institution      :    U California, Los Angeles
   E-Mail           :    plu@mednet.ucla.edu
   Proposal ID      :    24


   Publications:


1  Becker B, Lu P, Woo E, Kim M, Cummings J
   Insight into memory and mood functioning in amnestic mild cognitive impairment
   2008   Abstract  133rd Annual Meeting of the American Neurological Association, Salt Lake City, UT , 

   ACCEPTED





   Proposal Description:
   Specific Aim #1: Examine the relationship between depression and anosognosia in  subjects with MCI. Hypothesis #1: We hypothesize that MCI  subjects with reduced insight (MCI-UNAWARE) will experience  lower levels of depression than individuals with intact insight  (MCI-AWARE).    Specific Aim #2: Examine the relationship between executive functioning and  anosognosia in patients with MCI. Hypothesis #2: we expect that  MCI subjects with executive impairment (MCI-EXEC) will display  poorer insight than MCI subjects without executive impairment  (MCI-NONEXEC).    Specific Aim #3: Examine whether the presence of anosognosia is predictive of onset of dementia. Hypothesis #3: We hypothesize that MCIUNAWARE  participants will progress to dementia at a higher rate  than MCI-AWARE subjects.